the semple-rowland laboratory

Verrier JD, Madorsky I, Coggin WE, Geesey M, Hochman M, Walling E, Daroszewski D, Eccles KS, Ludlow R, Semple-Rowland SL (2011) Bicistronic lentiviruses containing a viral 2A cleavage sequence reliably co-express two proteins and restore vision to an animal model of LCA1. PLoS ONE online link

Anastas SB, Mueller D, Semple-Rowland SL, Breunig JJ, Sarkisian MR (2011) Failed cytokinesis of neural progenitors in citron kinase-deficient rats leads to multiciliated neurons. Cereb Cortex. 21:338-44.

Jackson TC, Verrier JD, Semple-Rowland S, Kumar A, Foster TC (2010) PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus. J Neurochem. 115:941-55.

Verrier JD, Semple-Rowland S, Madorsky I, Papin JE, Notterpek L (2010) Reduction of Dicer impairs Schwann cell differentiation and myelination. J Neurosci Res. 88:2558-68.

Semple-Rowland SL, Coggin WE, Geesey M, Eccles KS, Abraham L, Pachigar K, Ludlow R, Khani SC, Smith WC (2010) Expression characteristics of dual-promoter lentiviral vectors targeting retinal photoreceptors and Müller cells. Mol Vis.16:916-34.

Janisch KM, Kasanuki JM, Naumann MC, Davis RJ, Lin CS, Semple-Rowland S, Tsang SH (2009) Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons. Biochem Biophys Res Commun. 390:1149-53.

Foster TC, Rani A, Kumar A, Cui L, Semple-Rowland SL (2008) Viral vector-mediated delivery of estrogen receptor-alpha to the hippocampus improves spatial learning in estrogen receptor-alpha knockout mice. Mol Ther. 16:1587-1593.

Semple-Rowland SL, Eccles KS, Humberstone EJ (2007) Targeted expression of two proteins in neural retina using self-inactivating, insulated lentiviral vectors carrying two internal independent promoters. Mol Vis. 13:2001-2011. online link

Williams M, Coleman JE, Haire SE, Aleman T, Cideciyan A, Sokal I, Palczewski K, Jacobson, S, Semple-Rowland SL. (2006) Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Medicine 3(6): e201 (open access pdf)

Haire SE, Pang J, Boye SL, Sokal I, Craft CM, Palczewski K, Hauswirth WW, Semple-Rowland SL. (2006) Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Invest Ophthalmol Vis Sci. 47::3745-3753.

Zhang Y, Semple-Rowland SL (2005) Rhythmic expression of clock-controlled genes in retinal photoreceptors is sensitive to 18-beta-glycyrrhetnic acid and 18-alpha-glycyrrhetnic acid-3-hemisuccinate. Mol Brain Res. 135, 30-39.

Coleman JE, Semple-Rowland SL (2005) GC1 deletion prevents light-dependent arrestin translocation in mouse cone photoreceptor cells. Invest. Ophthalmol. Vis. Sci. 46, 12-16.

Coleman JE, Wu K, Fülle H-J, Semple-Rowland SL (2004) The 5' flanking sequence of the human retinal guanylyl cyclase-1 gene acquires a photoreceptor cell-restricted activity pattern over the course of retinal development. Mol Vis. 10:720-727. online link

Coleman JE, Zhang Y, Brown GE, Semple-Rowland SL. (2004) Cone cell survival and downregulation of GCAP1 protein in the retinas of GC1 knockout mice. Invest. Ophthalmol. Vis. Sci. 45, 3397-3403.

Zhang Y, Coleman JE, Fuchs GE, Semple-Rowland SL.(2003) Circadian oscillator function in embryonic retina and retinal explant cultures. Brain Res Mol Brain Res. 26;114:9-19.

Coleman JE, Huentelman MJ, Kasparov S, Metcalfe BL, Paton JF, Katovich MJ, Semple-Rowland SL, Raizada MK. (2003) Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo. Physiol Genomics. 12:221-8. Epub 2002 Dec 10.

Coleman JE, Fuchs GE, Semple-Rowland SL. (2002) Analyses of the guanylate cyclase activating protein-1 gene promoter in the developing retina. Invest Ophthalmol Vis Sci. 43:1335-43.

Semple-Rowland SL, Tepedino M, Coleman JE. (2001) Pinopsin mRNA levels are significantly elevated in the pineal glands of chickens carrying a null mutation in guanylate cyclase-1. Brain Res Mol Brain Res. 97:51-8.

Larkin P, Semple-Rowland SL. (2001) A null mutation in guanylate cyclase-1 alters the temporal dynamics and light entrainment properties of the iodopsin rhythm in cone photoreceptor cells. Brain Res Mol Brain Res. 92:49-57.

Streit WJ, Hurley SD, McGraw TS, Semple-Rowland SL. (2000) Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration. J Neurosci Res. 61:10-20.

Semple-Rowland SL, Lee NR. (2000) Avian models of inherited retinal disease. Methods Enzymol. 316:526-36.

Semple-Rowland SL, Cheng KM. (1999) rd and rc chickens carry the same GC1 null allele (GUCY1*). Exp Eye Res. 69:579-81.

Semple-Rowland SL, Larkin P, Bronson JD, Nykamp K, Streit WJ, Baehr W. (1999) Characterization of the chicken GCAP gene array and analyses of GCAP1, GCAP2, and GC1 gene expression in normal and rd chicken pineal. Mol Vis. 5:14.

Larkin P, Baehr W, Semple-Rowland SL. (1999) Circadian regulation of iodopsin and clock is altered in the retinal degeneration chicken retina. Brain Res Mol Brain Res. 70:253-63.

Hurley SD, Walter SA, Semple-Rowland SL, Streit WJ. (1999) Cytokine transcripts expressed by microglia in vitro are not expressed by ameboid microglia of the developing rat central nervous system. Glia. 25:304-9.

Huang Y, Cideciyan AV, Papastergiou GI, Banin E, Semple-Rowland SL, Milam AH, Jacobson SG. (1999) Relation of optical coherence tomography to microanatomy in normal and rd chickens. Invest Ophthalmol Vis Sci. 39:2405-16.

Streit WJ, Semple-Rowland SL, Hurley SD, Miller RC, Popovich PG, Stokes BT. (1998) Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis. Exp Neurol. 152:74-87.

Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W. (1998) A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proc Natl Acad Sci U S A. 95:1271-6.

Hogsette JA, Wilson HR, Semple-Rowland SL. (1997) Effects on white Leghorn hens of constant exposure to ultraviolet light from insect traps. Poult Sci. 76:1134-7.

Semple-Rowland SL, Mahatme A, Rowland NE. (1996) Effects of dexfenfluramine or 5,7-dihydroxytryptamine on tryptophan hydroxylase and serotonin transporter mRNAS in rat dorsal raphe. Brain Res Mol Brain Res. 41:121-7.

Semple-Rowland SL, Gorczyca WA, Buczylko J, Helekar BS, Ruiz CC, Subbaraya I, Palczewski K, Baehr W. (1996) Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina. FEBS Lett. 385:47-52.

Semple-Rowland SL, Mahatme A, Popovich PG, Green DA, Hassler G Jr, Stokes BT, Streit WJ. (1995) Analysis of TGF-beta 1 gene expression in contused rat spinal cord using quantitative RT-PCR. J Neurotrauma. 12:1003-14.

Semple-Rowland SL, Green DA. (1994) Molecular characterization of the alpha'-subunit of cone photoreceptor cGMP phosphodiesterase in normal and rd chicken. Exp Eye Res. 59:365-72.

Semple-Rowland SL, Green DA. (1994) Molecular and biochemical analyses of iodopsin in rd chick retina. Invest Ophthalmol Vis Sci. 1994 35:2550-7. Erratum in: Invest Ophthalmol Vis Sci 1994 35:3126.

Supler ML, Semple-Rowland SL, Streit WJ. (1994) Oligodendrocytes produce low molecular weight glycoproteins containing N-acetyl-D-glucosamine in their Golgi apparatus. Glia. 10:193-201.

Rowland NE, Kalehua AN, Li BH, Semple-Rowland SL, Streit WJ. (1993) Loss of serotonin uptake sites and immunoreactivity in rat cortex after dexfenfluramine occur without parallel glial cell reactions. Brain Res. 624:35-43.

Semple-Rowland SL, van der Wel H. (1992) Visinin: biochemical and molecular comparisons in normal and rd chick retina. Biochem Biophys Res Commun. 183:456-61.

Semple-Rowland SL, Adamus G, Cohen RJ, Ulshafer RJ. (1991) A reliable two-dimensional gel electrophoresis procedure for separating neural proteins. Electrophoresis. 12:307-12.

Semple-Rowland SL. (1991) Expression of glial fibrillary acidic protein by Muller cells in rd chick retina. J Comp Neurol. 305:582-90.

Semple-Rowland SL, Ulshafer RJ. (1989) Analysis of proteins in developing rd (retinal degeneration) chick retina using two-dimensional gel electrophoresis. Exp Eye Res. 49:665-75.

Semple-Rowland SL. (1989) Two-dimensional gel electrophoretic analysis of proteins in the rd chick retina. Prog Clin Biol Res. 314:455-65.

Semple-Rowland SL, Dawson WW. (1987) Retinal cyclic light damage threshold for albino rats. Lab Anim Sci. 37:289-98.

Semple-Rowland SL, Dawson WW. (1987) Cyclic light intensity threshold for retinal damage in albino rats raised under 6 lx. Exp Eye Res. 44:643-61.

Semple-Rowland SL, Dawson WW. (1986) The effects of dim cyclic light on pigment epithelial function in the albino rat. Curr Eye Res. 5:137-47.

Dawson WW, Michels M, Semple-Rowland SL. (1984) Results from a simple laser color perimeter. Doc Ophthalmol. 57:181-6.

Berger TW, Semple-Rowland S, Bassett JL. (1981) Hippocampal polymorph neurons are the cells of origin for ipsilateral association and commissural afferents to the dentate gyrus. Brain Res. 224:329-36.

Semple-Rowland SL, Goldstein EB. (1981) Segregation of vitamin A1 and vitamin A2 cone pigments in the bullfrog retina. Vision Res. 21:825-8.